Season 1
- Episode 1 Fat Wagon and the False Power of Ego 10/10/2011
- Episode 2 Author Terry McMillan and Her Gay Ex-Husband Jonathan Plummer 10/11/2011
- Episode 3 Jim Carrey, J.K. Rowling and Ralph Lauren 10/12/2011
- Episode 4 Ellen Comes Out 10/13/2011
- Episode 5 The Famous Car Giveaway 10/14/2011
- Episode 6 How Lady Gaga Found Her Calling 10/17/2011
- Episode 7 Aging Well With Cybill Shepherd, Bo Derek and Beverly Johnson 10/18/2011
- Episode 8 Skinheads Then and Now 10/19/2011
- Episode 9 Paula Deen's Rise to the Top 10/20/2011
- Episode 10 Behind the Scenes of The Flash Mob 10/21/2011
- Episode 11 Actress Tracey Gold and the Cops Who Saved Jaycee Dugard 10/24/2011
- Episode 12 5 Sisters With 500 Grudges: Update 10/25/2011
- Episode 13 Dr. Phil's Best Marriage Advice 10/26/2011
- Episode 14 Faith the Two-Legged Dog 10/27/2011
- Episode 15 Australia and the Mariah Carey Moment 10/28/2011
- Episode 16 Best Lifesaving Lessons 10/31/2011
- Episode 17 Overcoming the Worst Day of Your Life 11/1/2011
- Episode 18 Director James Cameron and Author Toni Morrison 11/2/2011
- Episode 19 Oprah and Gayle Go Back in Time 11/3/2011
- Episode 20 Joy Rising: Princess for a Day and Our Best Dream Come True Moments 11/4/2011
- Episode 21 A Suburban Mother's Nightmare: What We Learned 11/7/2011
- Episode 22 The Mom Who Shopped Her Family Broke 11/8/2011
- Episode 23 A Mother's Deadly Mistake: The Ultimate Lesson 11/9/2011
- Episode 24 Oprah's Lifeclass Field Trip: Newton's Third Law 11/10/2011
- Episode 25 Oprah's All-Time Favorite Lesson 11/11/2011
Season 2
- Episode 1 Tour: Oprah and Iyanla Vanzant Live from St. Louis; Stopping the Pain 3/26/2012
- Episode 2 Tour: Oprah & Tony Robbins Live From New York 4/2/2012
- Episode 3 Tour: Oprah & Bishop T.D. Jakes Live With Purpose 4/9/2012
- Episode 4 Oprah & Lifeclass Teachers Live from Toronto/The Power of Forgiveness 4/16/2012
- Episode 5 Oprah & Deepak Chopra/Spiritual Solutions 4/23/2012
- Episode 6 Toronto with Bishop T.D. Jakes, Iyanla Vanzant, Deepak Chopra and Tony Robbins 4/30/2012
- Episode 7 Oprah and Iyanla Vanzant/Growing Beyond Guilt 7/29/2012
- Episode 8 Oprah and Iyanla Vanzant/Hard Conversations 8/5/2012